htra1 inhibitor
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「htra1 inhibitor」文章包含有：「AllostericinhibitionofHTRA1activitybyaconformational...」、「Developmentofatherapeuticanti」、「HtrA1serineproteaseinhibitssignalingmediatedby...」、「Phase1StudyoftheAnti」、「PlacentalHTRA1cleavesα1」、「SerineProteaseHtrA1AssociateswithMicrotubulesand...」、「ThetrimericserineproteaseHtrA1formsacage」
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Allosteric inhibition of HTRA1 activity by a conformational ...
https://pubmed.ncbi.nlm.nih.go
Here, we describe the allosteric inhibition mechanism of HTRA1 by a clinical Fab fragment, currently being evaluated for GA treatment. Using ...
Development of a therapeutic anti
https://www.pnas.org
We have developed a potent anti-HtrA1 Fab inhibitor of HtrA1 proteolytic activity in the retina as a potential therapeutic for treating AMD.
HtrA1 serine protease inhibits signaling mediated by ...
https://pubmed.ncbi.nlm.nih.go
Taken together, these data indicate that HtrA1 protease is a novel inhibitor of Tgfbeta family members. Publication types. Research Support, Non-U.S. Gov't ...
Phase 1 Study of the Anti
https://pubmed.ncbi.nlm.nih.go
HTRA1 inhibition may preserve retinal integrity and slow disease progression in geographic atrophy (GA) secondary to age-related macular ...
Placental HTRA1 cleaves α1
https://pubmed.ncbi.nlm.nih.go
Placental HTRA1 cleaves α1-antitrypsin to generate a NET-inhibitory peptide. Blood. 2021 Sep 16;138(11):977-988. doi: ...
Serine Protease HtrA1 Associates with Microtubules and ...
https://www.ncbi.nlm.nih.gov
SKOV3 cells with endogenous HtrA1 expression were lysed in wash buffer supplemented with complete protease inhibitors from Roche, centrifuged at 10,000 × g for ...
The trimeric serine protease HtrA1 forms a cage
https://pubmed.ncbi.nlm.nih.go
High temperature requirement A1 (HtrA1) is a trypsin-fold serine protease implicated in the progression of age-related macular degeneration ...